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[thiazin]

Уважаемые коллеги, посмотрите пожалуйста по базам синтез и реакции азидоацетамида

CAS Registry Number: 1816-91-7

[N-]=[N+]=N/CC(N)=O

[Serty]

Reaxys

[Arkadii_Tarasevych]

SciФАЙНДЕР (6 ссылок):
1. Azolyl substituted carbonitrile derivatives as cathepsin S inhibitors and their preparation and use for the treatment of diseases By Burke, Michael Jason; Cogan, Derek; Gao, Donghong A.; Heim-Riether, Alexander; Hickey, Eugene Richard; Ramsden, Philip Dean; Thompson, David Charles; Xiong, Zhaoming From PCT Int. Appl. (2011), WO 2011109470 A1 20110909. Language: English, Database: CAPLUS
The invention relates to azolyl substituted carbonitrile derivs. of formula I, which are cathepsin S inhibitors and which are useful in the treatment of diseases. Compds. of formula I wherein each X is independently CH and N; R1 is (un)substituted C1-7 alkyl, (un)substituted C3-7 cycloalkyl, (un)substituted aryl, etc.; R2 is H and (un)substituted C1-7 alkyl; R1R2 taken together to form (un)substituted C3-7 cycloalkyl and (un)substituted C3-7 heterocyclyl; R3 is (un)substituted C(O)C1-7 alkyl, (un)substituted C(O)C3-7 cycloalkyl, (un)substituted C(O)aryl, etc.; R4 and R5 are independently H, (un)substituted C1-7 alkyl, (un)substituted aryl, etc.; R4R5 taken together to form (un)substituted C3-7 cycloalkyl and (un)substituted C3-7 heterocyclyl; with provisions; and pharmaceutically acceptable salts thereof, are claimed. Example compd. II was prepd. by a general procedure (procedure given). All the invention compds. were evaluated for their cathepsin S inhibitory activity (biodata not given).
SubstancesReactions~0 Citings Full TextLink0 Comments 0 Tags 2. Mass spectrometric study of aliphatic α-carbonyl azides By Duarte, M. Filomena; Martins, Filipa; Fernandez, M. Tereza; Langley, G. John; Rodrigues, Paula; Barros, M. Teresa; Costa, M. Lourdes From Rapid Communications in Mass Spectrometry (2003), 17(9), 957-962. Language: English, Database: CAPLUS
A series of derivs. of 2-azidoacetic acid and 2-azidoacetone were synthesized and their behavior under electron ionization conditions was investigated. This paper reports the electron ionization fragmentation mechanisms for five aliph. α-carbonyl azides, which were clarified by accurate mass measurements and B/E linked scans. The substituent influences the abundance and the nature of the ions resulting from the mol. ion fragmentation.
SubstancesReactions~8 Citings Full TextLink0 Comments 0 Tags 3. Synthesis of N-acetamide C60 nitride and its performance of optical limiting By Tang, Guangshi; Zhu, Hesun; Song, Yinglin From Chinese Science Bulletin (2000), 45(2), 150-153. Language: English, Database: CAPLUS
N-acetamide C60 nitride (N-acetamide-1,2-dihydro-1,2-aza-fullerene [60]) was prepd. by the reaction of C60 and azidoacetamide and initially characterized. The target product was formed through an intermediate triazoline. A computational study showed that N-nitride structure is thermodynamically more stable by using the semi-empirical AM1 SCF-MO method. The properties of optical limiting were tested by using a double frequency Nd:YAG pulse laser system and showed that the optical limiting mechanism is characterized by reverse satn. absorption. At wavelength of 532 nm, compared with optical limiting for ns pulse, this new material has good optical limiting properties for ps pulse.
SubstancesReactions~1 Citing Full TextLink0 Comments 0 Tags 4. The formation of pyrazines from N-β-keto iminotriphenylphosphoranes; iminophosphorane-mediated syntheses of 2,2,4,4-tetraphenyl-N,N'-bis(1-methyl-2-oxobutyl)cyclobutane-1,3-diimine; 1,3,4-oxadiazoles; 2-amino-3,5-dihydroimidazol-4-ones; and 2-(diphenylmethyl)-1,5-dihydroimidazol-4-one By Froeyen, Paul From Phosphorus, Sulfur and Silicon and the Related Elements (1991), 63(3-4), 283-93. Language: English, Database: CAPLUS
The aza-Wittig reaction of EtCOCHMeN3 with Ph2C:C:O and Ph3P gave Ph2C:C:NCHMeCOEt, which dimerized spontaneously to title diimine I. Iminophosphoranes were used to prep. dihydroimidazolones, e.g., II (R = H, R1 = Ph, cyclohexyl; R = Me, R1 = Ph). Oxadiazoles III (R2 = H, Me, NO2, Cl) were prepd. from [(acylamino)imino]triphenylphosphoranes. The mechanism of decompn. of unstable [(β-oxoalkyl)imino]triphenylphosphoranes to pyrazines and Ph3PO was examd.
SubstancesReactions~1 Citing Full TextLink0 Comments 0 Tags 5. New syntheses with azido radicals and oxygen α-azido ketones and α-azido esters By Minisci, Francesco; Gallo, Remo From Chimica e l'Industria (Milan, Italy) (1965), 47(2), 178-80. Language: Italian, Database: CAPLUS
cf. CA 57, 14913f. To 26 g. styrene, 16 g. NaN3, and 10 g. Fe2(SO4)3 in MeOH were added with stirring 24 g. 36% H2O2 and 70 g. FeSO4.7H2O in 280 cc. MeOH under O at 0°. The product was dild. with H2O and extd. with ether to give 23 g. PhCOCH2N3, absorbing at 4.75 and 5.9 μ. A small amt. of BzH was. formed by decompn. Similarly, other azido ketones were prepd. (starting compd. and m.p. or b.p. of the product given): transstilbene, 84° (decompn.); 1-hexene, 66-7°/1 mm. (decompn.). α-Methylstyrene gave mainly acetophenone, probably by decompn. of the unstable azido compd. Vinyl ethyl ether (25 g.) was converted to 6 g. N3CH2CO2Et, b0.7 40-3°; amide m. 58°. Acrylonitrile (53 g.) yielded 3 g. N3CH2CO2Me, b0.6 35°; amide m. 58°.
SubstancesReactions~0 Citings Full TextLink0 Comments 0 Tags 6. The Triazo Group. Part I. Triazoacetic Acid and Triazoacetone (Acetonylazoimide) By Forster, Martin Onslow; Fierz, Hans Edward From Proceedings of the Chemical Society, London (1908), 23, 258. Language: Unavailable, Database: CAPLUS
The authors have prepd. some of the simplest typical compds. contg. the triazo-group in the complex, -CH(N3)-CO-. Triazoacetic acid is a colorless, cryst. substance, m. 16°. It is a strong acid, and has an odor resembling butyric acid, although not so marked, and explodes when heated. Silver salt, slightly decompd. when exposed to light. Et ester, colorless oil, b2 45°, odor recalling chloroform. Triazoacetamide, long colorless needles, m. 58°. The derivs. of triazoacetic acid are less reactive towards conc. H2SO4 than is usually the case with compds. contg. the triazo group. A neutral soln. of potassium triazoacetate can be boiled without decompn., but does break down in the presence of free alkali. Triazoacetone (acetonylazoimide) is a colorless oil, b2 54°, Its odor somewhat resembling that of chloroform. It is moderately sol. in water, and is decompd. by aq. alkali. Dropped on a hot iron plate, it explodes, and conc. H2SO4 decomps. it immediately. Semicarbazone, long lustrous needles, m. 152°. The triazo-derivs. of acetone and acetic ester were prepd. by the action of sodium azide on the resp. chlorine compds.

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