+++Поиск по реаксис и сайфайндер

[RammDen]

Уважаемые коллеги! Помогите, пожалуйста, найти методики синтеза и физические свойства следующего соединения:
Название: Torasemide.
CAS: 56211-40-6
PubChem: 7847448
Mol file:

Torsemide.mol

Спасибо!

[Chem_DM]

Реаксис.

[suprachemister]

Experimental Properties: Biological Chemical Lipinski and Related Spectra Thermal
Top Biological Properties Value Condition Note
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (2) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (3) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (4) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (5) CAS
Half-Life (Biological) See full text (5) CAS
Half-Life (Biological) See full text (3) CAS
Half-Life (Biological) See full text (4) CAS
Half-Life (Biological) See full text (6) CAS
LC50 See full text (8) CAS
Top Chemical Properties Value Condition Note
Acid/Base Dissociation Constant (Ka/Kb) See full text (1) CAS
logP See full text (8) CAS
Top Lipinski and Related Properties Value Condition Note
logP See full text (8) CAS
Top Spectra Properties Value Condition Note
IR Absorption Spectrum See full text (7) CAS
Mass Spectrum See full text (7) CAS
Mass Spectrum See full text (9) CAS
Mass Spectrum See full text (10) CAS
Mass Spectrum See full text (11) CAS
UV and Visible Absorption Spectrum See full text (14) CAS
Top Thermal Properties Value Condition Note
Melting Point 163-164 °C (12) IC
Melting Point 163-164 °C (13) APC
Melting Point See full text (7) CAS

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(4) Obach, R. Scott; Drug Metabolism and Disposition 2008, V36(7), P1385-1405 CAPLUS
(5) Vormfelde, Stefan Viktor; Clinical Pharmacology & Therapeutics (St. Louis, MO, United States) 2004, V76(6), P557-566 CAPLUS
(6) Lee, Dae Y.; Biopharmaceutics & Drug Disposition 2005, V26(5), P173-182 CAPLUS
(7) Rollinger, J. M.; Journal of Thermal Analysis and Calorimetry 2003, V73(2), P519-526 CAPLUS
(8) Sanderson, Hans; Toxicology Letters 2009, V187(2), P84-93 CAPLUS
(9) Goebel, Catrin; Analytica Chimica Acta 2004, V502(1), P65-74 CAPLUS
(10) Vonaparti, A.; Rapid Communications in Mass Spectrometry 2010, V24(11), P1595-1609 CAPLUS
(11) Dikunets, M. A.; Journal of Analytical Chemistry 2009, V64(8), P832-842 CAPLUS
(12) Delarge, J.; Annales Pharmaceutiques Francaises 1978, V36(7-8), P369-79 CAPLUS
(13) Milne, G. W. A.; Drugs: Synonyms & Properties 2000, P1280 pp. CAPLUS
(14) Sankar, D. Gowri; Asian J. Chem. 2006, V18(4), P3247-3248 CAPLUS

[RammDen]

Спасибо огромное, дорогие коллеги!