Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity
Robert L. Dow*, Philip A. Carpino, John R. Hadcock, Shawn C. Black†, Philip A. Iredale, Paul DaSilva-Jardine, Steven R. Schneider, Ernest S. Paight, David A. Griffith, Dennis O. Scott, Rebecca E. O’Connor and Chudy I. Nduaka
J. Med. Chem., 2009, 52 (9), pp 2652–2655
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http://dx.doi.org/10.1021/jm900255t
