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Volume 16, Issue 21, 1 November 2006, Pages 5561-5566
Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors

Hassan El Abdellaoui, Chamakura V.N.S. Varaprasada, Dinesh Barawkara, Subrata Chakravartya, Andreas Madernaa, Robert Tama, Huanming Chena, Matt Allana, Jim Z. Wua, Todd Applebya, Shunqi Yana, Weijian Zhanga, Stanley Langa, Nanhua Yaoa, Robert Hamatakea and Zhi Honga

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http://dx.doi.org/10.1016/j.bmcl.2006.08.048 

Volume 16, Issue 13, 1 July 2006, Pages 3444-3448
Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists

Blaise Lippa, Joel Morris, Matthew Corbett, Tricia A. Kwan, Mark C. Noe, Sheri L. Snow, Thomas G. Gant, Melchiorra Mangiaracina, Heather A. Coffey, Barbara Foster, Elisabeth A. Knauth and Matthew D. Wessel

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http://dx.doi.org/10.1016/j.bmcl.2006.04.003 

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