Triazene
Triazene
Добрый день, может кто-нибудь подскажет характеристики для 4,4* - (1 - Triazene) bis (benzenecarboximidamine) интересуют Т плавления, если есть то и УФ спектр. Заранее благодарен.
Ты структурку то в обменник сбрось, уж больно непонятная, и в www.aist.go.jp посмотри
Bibliographic Information
Basic diazoaminobenzene compounds. Jensch, Heinrich. (Farbwerke Hoechst AG). (1954), US 2673197 19540323 Patent language unavailable. CAN 49:32522 AN 1955:32522 CAPLUS
Patent Family Information
Patent No. Kind Date Application No. Date
US 2673197 19540323 US
Abstract
The starting materials for this coupling reaction are the hydrochlorides of p-aminobenzamidines, m-aminobenzamidine, p-amino-phenylguanidine, m-aminophenylguanidine, p-aminobenzylideneaminoguanidine and m-aminobenzylideneam-inoguanidine. These diazoamino compds. are very active against blood parasites, such as trypanosomes and babesia. A soln. of 27 g. p-aminobenzamidine-HCl in 120 mL. H2O is acidified with 39 mL. concd. HCl, whereupon the dihydrochloride ppts. While stirring, 5.3 g. NaNO2 soln. is added, then 150 mL. satd. soln. of Na acetate. The diazoamino compd. (I), filtered off and washed with dil. NaCl, then ice cold water, m. 270° (from acetone) (hydrochloride); free base, m. 210°; acetate, m. 246°. Likewise, m-aminobenzamidine-HCl yields the diazoamino compd.-HCl, m. 190° (decompn.); free base, m. 199°; acetate, m. 232°. The diazonium salt from 12 g. p-aminobenzamidine-HCl in 60 mL. H2O, 17 mL. concd. HCl, and 4.7 g. of NaNO2 are mixed with a soln. of 15.5 g. m-aminobenzamidine-2HCl in 40 mL. H2O, 85 mL. satd. Na acetate added to the mixt., and after standing on ice, the ppt. is filtered off and washed with dil. NaCl, then ice water. The product is dissolved in warm MeOH and acetone added to ppt. p-H2NC(: NH)C6H4NHN: NC6H4C-(: NH)NH2-m' (II).2HCl, m.n 262° (decompn.); II, m. 165-6°. After hydrolysis of p-AcNHC6H4NHC(:NH)NH2H2CO3 with acid, the diazoamino compd. is prepd. as described for I; dihydrochloride, m. 218-9°; carbonate, m. 170-1° (decompn.); free base, m. 204° (decompn.). p-Aminobenzylideneaminoguanidine carbonate yields its corresponding diazoamino compd. in the manner used for I; dihydrochloride, m. 204-5° (decompn.); free base (IIA), m. 198° (decompn.); acetate, m. 193° (decompn.). pH2NC(: NH)NHN:CHC6H4NHN: NC6H4C(:NH)NH2-p' (III), prepd. from diazotized p-aminobenzamidine-HCl and p-aminobenzylideneaminoguanidine carbonate, m. 208° (decompn.); di-HCl salt, m. 219-20° (decompn.). IIA is also obtained from p-OHCC6H4NHN:NC6H4CHO-p and aminoguanidine nitrate.
m-H2NC(:NH)NHC6H4NHN: N-C6H4NHC(:NH)NH2-p m. 149-50° (di-HCl salt, m. 185°); the carbonate of the m,m'-analog (IV) m. 94° (IV.2HOAc, m. 173°).
Indexing -- Section 10 (Organic Chemistry)
Parasiticides
Trypanocides
(1,3-diphenyltriazene basic derivs.)
Guanidine, [p-[(m-guanidinophenyl)triazeno]-phenyl]-
536-71-0, Benzamidine, 4,4'-diazoaminodi-
_
15687-11-3, Benzamidine, 3,3'-diazoaminodi-
639070-20-5, Guanidine, [m-(m-amidinophenyldiazoamino)phenyl]-
642469-33-8, Guanidine, 1,1'-[diazoaminobis(p-phenyl-enemethylidynenitrilo)]di-
725735-10-4, Benzamidine, p-[[a-(amidinohydrazono)-p-tolyl]triazeno]-
727998-81-4, Guanidine, 1,1'-(diazoaminodi-p-phenylene)di-
777953-83-0, Benzaldehyde, p-(p-amidinophenyldiazoamino)-, amidinohydrazone
778624-37-6, Benzamidine, 3,4'-diazoaminodi-
(and salts)
136-35-6, Triazene, 1,3-diphenyl-
(basic derivs. of)
639044-63-6, Guanidine, [p-[(m-guanidinophenyl)triazeno]-phenyl]-, dihydrochloride
640287-86-1, Benzamidine, p-(p-guanidinophenyldiazoamino)-, dihydrochloride
640291-54-9, Benzamidine, p-(p-guanidinophenyldiazoamino)-
(prepn. of)
Bibliographic Information
4,4'-Diamidinodiazoaminobenzene, a new remedy against Trypanosoma and Babesia infections. Jensch, Heinrich. Farbwerke Hochst. A.-G., Frankfurt a. M./Hochst, Germany. Arzneimittel-Forschung (1955), 5 634-5. CODEN: ARZNAD ISSN: 0004-4172. Journal language unavailable. CAN 50:17410 AN 1956:17410 CAPLUS
Abstract
Report on a new drug, the aceturic salt of 4-[4-H2NC(:NH)C6H4NHN:N]C6H4C(:NH)NH2 (Berenil) which shows excellent results in African nagana disease and in piroplasmosis.
Bibliographic Information
Basic diazoaminobenzene compounds. (Farberke Hoechst AG vorm. Meister Lucius & Bruning). (1955), GB 728457 19550420 Patent language unavailable. CAN 49:53679 AN 1955:53679 CAPLUS
Патенты доступны бесплатно через Espacenet
Basic diazoaminobenzene compounds. Jensch, Heinrich. (Farbwerke Hoechst AG). (1954), US 2673197 19540323 Patent language unavailable. CAN 49:32522 AN 1955:32522 CAPLUS
Patent Family Information
Patent No. Kind Date Application No. Date
US 2673197 19540323 US
Abstract
The starting materials for this coupling reaction are the hydrochlorides of p-aminobenzamidines, m-aminobenzamidine, p-amino-phenylguanidine, m-aminophenylguanidine, p-aminobenzylideneaminoguanidine and m-aminobenzylideneam-inoguanidine. These diazoamino compds. are very active against blood parasites, such as trypanosomes and babesia. A soln. of 27 g. p-aminobenzamidine-HCl in 120 mL. H2O is acidified with 39 mL. concd. HCl, whereupon the dihydrochloride ppts. While stirring, 5.3 g. NaNO2 soln. is added, then 150 mL. satd. soln. of Na acetate. The diazoamino compd. (I), filtered off and washed with dil. NaCl, then ice cold water, m. 270° (from acetone) (hydrochloride); free base, m. 210°; acetate, m. 246°. Likewise, m-aminobenzamidine-HCl yields the diazoamino compd.-HCl, m. 190° (decompn.); free base, m. 199°; acetate, m. 232°. The diazonium salt from 12 g. p-aminobenzamidine-HCl in 60 mL. H2O, 17 mL. concd. HCl, and 4.7 g. of NaNO2 are mixed with a soln. of 15.5 g. m-aminobenzamidine-2HCl in 40 mL. H2O, 85 mL. satd. Na acetate added to the mixt., and after standing on ice, the ppt. is filtered off and washed with dil. NaCl, then ice water. The product is dissolved in warm MeOH and acetone added to ppt. p-H2NC(: NH)C6H4NHN: NC6H4C-(: NH)NH2-m' (II).2HCl, m.n 262° (decompn.); II, m. 165-6°. After hydrolysis of p-AcNHC6H4NHC(:NH)NH2H2CO3 with acid, the diazoamino compd. is prepd. as described for I; dihydrochloride, m. 218-9°; carbonate, m. 170-1° (decompn.); free base, m. 204° (decompn.). p-Aminobenzylideneaminoguanidine carbonate yields its corresponding diazoamino compd. in the manner used for I; dihydrochloride, m. 204-5° (decompn.); free base (IIA), m. 198° (decompn.); acetate, m. 193° (decompn.). pH2NC(: NH)NHN:CHC6H4NHN: NC6H4C(:NH)NH2-p' (III), prepd. from diazotized p-aminobenzamidine-HCl and p-aminobenzylideneaminoguanidine carbonate, m. 208° (decompn.); di-HCl salt, m. 219-20° (decompn.). IIA is also obtained from p-OHCC6H4NHN:NC6H4CHO-p and aminoguanidine nitrate.
m-H2NC(:NH)NHC6H4NHN: N-C6H4NHC(:NH)NH2-p m. 149-50° (di-HCl salt, m. 185°); the carbonate of the m,m'-analog (IV) m. 94° (IV.2HOAc, m. 173°).
Indexing -- Section 10 (Organic Chemistry)
Parasiticides
Trypanocides
(1,3-diphenyltriazene basic derivs.)
Guanidine, [p-[(m-guanidinophenyl)triazeno]-phenyl]-
536-71-0, Benzamidine, 4,4'-diazoaminodi-
_
15687-11-3, Benzamidine, 3,3'-diazoaminodi-
639070-20-5, Guanidine, [m-(m-amidinophenyldiazoamino)phenyl]-
642469-33-8, Guanidine, 1,1'-[diazoaminobis(p-phenyl-enemethylidynenitrilo)]di-
725735-10-4, Benzamidine, p-[[a-(amidinohydrazono)-p-tolyl]triazeno]-
727998-81-4, Guanidine, 1,1'-(diazoaminodi-p-phenylene)di-
777953-83-0, Benzaldehyde, p-(p-amidinophenyldiazoamino)-, amidinohydrazone
778624-37-6, Benzamidine, 3,4'-diazoaminodi-
(and salts)
136-35-6, Triazene, 1,3-diphenyl-
(basic derivs. of)
639044-63-6, Guanidine, [p-[(m-guanidinophenyl)triazeno]-phenyl]-, dihydrochloride
640287-86-1, Benzamidine, p-(p-guanidinophenyldiazoamino)-, dihydrochloride
640291-54-9, Benzamidine, p-(p-guanidinophenyldiazoamino)-
(prepn. of)
Bibliographic Information
4,4'-Diamidinodiazoaminobenzene, a new remedy against Trypanosoma and Babesia infections. Jensch, Heinrich. Farbwerke Hochst. A.-G., Frankfurt a. M./Hochst, Germany. Arzneimittel-Forschung (1955), 5 634-5. CODEN: ARZNAD ISSN: 0004-4172. Journal language unavailable. CAN 50:17410 AN 1956:17410 CAPLUS
Abstract
Report on a new drug, the aceturic salt of 4-[4-H2NC(:NH)C6H4NHN:N]C6H4C(:NH)NH2 (Berenil) which shows excellent results in African nagana disease and in piroplasmosis.
Bibliographic Information
Basic diazoaminobenzene compounds. (Farberke Hoechst AG vorm. Meister Lucius & Bruning). (1955), GB 728457 19550420 Patent language unavailable. CAN 49:53679 AN 1955:53679 CAPLUS
Патенты доступны бесплатно через Espacenet
Berenil
Molecular Formula
C14H15N7 · 2C4H7NO3
Molecular Weight
515.52
CAS Number
908-54-3
этот продается Sigma - значит в каталоге есть данные типа Тпл
Еще я думаю что УФ спектр данного соединения просто широкий горб - в моем опыте работы я НИ РАЗУ не смог извлечь ничего полезного из UV-vis
Вот в ИК связь азот-азот двойную должно быть видно около 1550-1600
Molecular Formula
C14H15N7 · 2C4H7NO3
Molecular Weight
515.52
CAS Number
908-54-3
этот продается Sigma - значит в каталоге есть данные типа Тпл
Еще я думаю что УФ спектр данного соединения просто широкий горб - в моем опыте работы я НИ РАЗУ не смог извлечь ничего полезного из UV-vis
Вот в ИК связь азот-азот двойную должно быть видно около 1550-1600
(Положил в exсhange в нормальном виде. Если нужны остальные обращайтесьslavert писал(а):Basic diazoaminobenzene compounds. Jensch, Heinrich. (Farbwerke Hoechst AG). (1954), US 2673197 19540323 Patent language unavailable. CAN 49:32522 AN 1955:32522 CAPLUS
На современном этапе развития химической науки открытие не может произойти чисто случайно [А. Дарзан, 1912]
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