+++Reaxys + SF

[boberk]

Здравствуйте! Помогите, пожалуйста, с поиском способов получения, физических свойств, в частности растворимости, такого соединения:
Decitabine
CAS No. 2353-33-5
SMILES O=C1/N=C(\N=C/N1[C@H]2O[C@@H]([C@@H](O)C2)CO)N
Временной период поиска: по умолчанию

Заранее большое спасибо.

[Chem_DM]

RX.

[suprachemister]

Experimental Properties: Biological Spectra Thermal
Top Biological Properties Value Condition Note
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (1) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (2) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (3) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (4) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (5) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (6) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (7) CAS
ADME (Absorption, Distribution, Metabolism, Excretion) See full text (8) CAS
Half-Life (Biological) See full text (4) CAS
Half-Life (Biological) See full text (5) CAS
Half-Life (Biological) See full text (6) CAS
Half-Life (Biological) See full text (7) CAS
Half-Life (Biological) See full text (8) CAS
Median Lethal Dose(LD50) 29.5 mg/kg Organism: mouse Route: intravenous (10) CAS
Median Lethal Dose(LD50) 22.2 mg/kg Organism: mouse Route: intravenous (10) CAS
Top Spectra Properties Value Condition Note
Mass Spectrum See full text (9) CAS
Top Thermal Properties Value Condition Note
Melting Point 198-199 °C (decomp) (11) CAS
Melting Point 196-198 °C (12) CAS

(1) Choi, Si Ho; British Journal of Haematology 2007, V138(5), P616-623 CAPLUS
(2) Lemaire, Maryse; Cancer Chemotherapy and Pharmacology 2009, V63(3), P411-416 CAPLUS
(3) Appleton, Kim; Journal of Clinical Oncology 2007, V25(29), P4603-4609 CAPLUS
(4) Jabbour, Elias; Cancer (Hoboken, NJ, United States) 2008, V112(11), P2341-2351 CAPLUS
(5) Blum, Kristie A.; British Journal of Haematology 2010, V150(2), P189-195 CAPLUS
(6) Zorn, Christoph S.; Clinical Cancer Research 2007, V13(7), P2136-2143 CAPLUS
(7) Anargyrou, Konstantinos; Leukemia Research 2010, V34(1), P6-17 CAPLUS
(8) Obach, R. Scott; Drug Metabolism and Disposition 2008, V36(7), P1385-1405 CAPLUS
(9) Liu, Zhongfa; Nucleic Acids Research 2007, V35(5), Pe31/1-e31/8 CAPLUS
(10) Momparler, R. L.; Drug and Chemical Toxicology (1977) 1981, V4(4), P373-81 CAPLUS
(11) NL 6414959 1965 CAPLUS
(12) Sorm, Frantisek; DE 1922702 A 1969 CAPLUS

способов получения

[boberk]

Спасибо огромное.