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C=C(C)C4CCC5(COC(=O)CCCC(=O)O)CCC3(C)C(CCC2C1(C)CCC(O)C(C)(C)C1CCC23C)C45

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References

1. Anti-fungal formulation of triterpene and essential oil
By Carlson, Robert M.; Gibson, David J.
From PCT Int. Appl. (2004), WO 2004089357 A2 20041021. Language: English, Database: CAPLUS
The present invention provides for pharmaceutical compns. that includes a triterpene (e.g., betulin) and an essential oil (Vicks, Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil. The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amt. of the pharmaceutical compn. to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection (no data).

2. Preparation of triterpene derivatives having antibacterial activity
By Krasutsky, Pavel A.; Carlson, Robert M.
From PCT Int. Appl. (2002), WO 2002026762 A1 20020404. Language: English, Database: CAPLUS
Triterpene derivs., such as I [R1 = H, OH, R2 = direct bond, carbonyl, oxy, thio, carbonyl oxy, oxy carbonyl, aryl, alkyl; R3, R4 = H, OH, alkyl, phosphate, alkanoyl, silyl, benzyl, benzoyl, glycoside; R5 = direct bond, carbonyl, oxy, thio, aryl, alkyl; R4R5 = oxo, oxime], or a pharmaceutically acceptable salt thereof, were prepd. for use as antibacterial agents. Thus, betulin-3,28-diphthalate II was prepd. by the reaction of betulin and phthalic anhydride. II had a min. inhibitory concn. of 2.3 μM against Staphylococcus aureus.

3. Preparation of triterpene derivatives having fungicidal activity against yeast
By Krasutsky, Pavel A.; Carlson, Robert M.
From PCT Int. Appl. (2002), WO 2002026761 A1 20020404. Language: English, Database: CAPLUS
Triterpene derivs., such as I [R1 = H, OH, R2 = direct bond, carbonyl, oxy, thio, aryl, alkyl; R3, R4 = H, OH, alkyl, phosphate, alkanoyl, silyl, glycoside; R5 = direct bond, carbonyl, oxy, thio, aryl, alkyl; R4R5 = oxo], or a pharmaceutically acceptable salt thereof, were prepd. for the manuf. of a medicament for treating fungal and yeast infection. Thus, betulin-28-phthalate II was prepd. by the reaction of betulin and phthalic anhydride. II showed antifungal activities against several human pathogenic fungi including Microsporum canis and Trichophyton rubrum at a concn. of 12.5μg/mL in DM...

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