+++Поиск по Реаксис
+++Поиск по Реаксис
Здравствуйте!
Помогите пожалуйста с поиском методик синтеза следующих соединений:
1. OCCN(CC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1)CCO
2. O=C(NC(CO)CO)NCCCl
3. O=C(NC1CCCCC1)NCCCl
4. O=C1CC[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@](C(CI)=O)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
5. OB(O)C(CCC1)N1C(OC(C)(C)C)=O
Заранее спасибо
Помогите пожалуйста с поиском методик синтеза следующих соединений:
1. OCCN(CC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1)CCO
2. O=C(NC(CO)CO)NCCCl
3. O=C(NC1CCCCC1)NCCCl
4. O=C1CC[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@](C(CI)=O)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
5. OB(O)C(CCC1)N1C(OC(C)(C)C)=O
Заранее спасибо
Последний раз редактировалось ineosA Вт июн 21, 2022 6:54 pm, всего редактировалось 1 раз.
Re: Поиск по Реаксис
Закройте выполненные предыдущие запросы.
Re: Поиск по Реаксис
Я все закрыл
Re: Поиск по Реаксис
например здесь приводил ссылки на незакрытые запросы (2 последние так и остались не закрыты)
поиск #1
из 2-[(4-bromobenzyl)-(2-hydroxy-ethyl)-amino]-ethanol
и
bis(pinacol)diborane
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 100℃; for 2.5h; Inert atmosphere;
Han, Jinsong; Chen, Ying; Yang, Chao; Liu, Ting; Wang, Mingping; Xu, Haojie; Zhang, Ling; Zheng, Canhui; Song, Yunlong; Zhu, Ju
[European Journal of Medicinal Chemistry, 2016, vol. 122, p. 684 - 701]
Experimental Procedure
4.2.2.1 N-(4-(6-bromoquinolin-4-yl)benzyl)-N-ethylethanamine (12a)
General procedure: To a stirred solution of 10 (1.00g, 4.00mmol) and K2CO3 (1.66g, 12.00mmol) in acetonitrile (20mL) was added dropwise diethylamine solution (1.20g, 16.00mmol) at room temperature for 2h. The solvent was evaporated in vacuo and the residue was then dissolved in EtOAc (50mL) and washed with water (20mL×3), the organic layers were washed with brine, and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure to provide the 11a (0.83g, 84.7% yield) as an off-white liquid. (0041) Then, a mixture of 11a (0.83g, 3.43mmol), bis(pinacolato)diboron (0.96g, 3.77mmol), PdCl2(dppf)-CH2Cl2 (0.084g, 0.103mmol) and potassium acetate (0.67g, 6.86mmol) in anhydrous 1,4-dioxane (15mL) was purged with argon and heated at 100°C for 2.5h. The reaction was then treated with 6 (1.20g, 3.60mmol), 2.0M aqueous Na2CO3 (5mL) and another portion of PdCl2(dppf)-CH2Cl2 (0.084g, 0.103mmol), then heated at 110°C for 12h under argon. The reaction mixture was cooled to room temperature, filtered, and concentrated. The final compound was purified by MPLC (ISCO CombiFlash purification system) (MeOH/DCM, eluted from 0% to 10%), The fractions were collected, concentrated to afford 12a (0.72g, 57.2% yield).
Код: Выделить всё
https://chemport.ru/forum/viewtopic.php?f=65&t=136557&p=1063601#p1063609
поиск #1
из 2-[(4-bromobenzyl)-(2-hydroxy-ethyl)-amino]-ethanol
и
bis(pinacol)diborane
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 100℃; for 2.5h; Inert atmosphere;
Han, Jinsong; Chen, Ying; Yang, Chao; Liu, Ting; Wang, Mingping; Xu, Haojie; Zhang, Ling; Zheng, Canhui; Song, Yunlong; Zhu, Ju
[European Journal of Medicinal Chemistry, 2016, vol. 122, p. 684 - 701]
Experimental Procedure
4.2.2.1 N-(4-(6-bromoquinolin-4-yl)benzyl)-N-ethylethanamine (12a)
General procedure: To a stirred solution of 10 (1.00g, 4.00mmol) and K2CO3 (1.66g, 12.00mmol) in acetonitrile (20mL) was added dropwise diethylamine solution (1.20g, 16.00mmol) at room temperature for 2h. The solvent was evaporated in vacuo and the residue was then dissolved in EtOAc (50mL) and washed with water (20mL×3), the organic layers were washed with brine, and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure to provide the 11a (0.83g, 84.7% yield) as an off-white liquid. (0041) Then, a mixture of 11a (0.83g, 3.43mmol), bis(pinacolato)diboron (0.96g, 3.77mmol), PdCl2(dppf)-CH2Cl2 (0.084g, 0.103mmol) and potassium acetate (0.67g, 6.86mmol) in anhydrous 1,4-dioxane (15mL) was purged with argon and heated at 100°C for 2.5h. The reaction was then treated with 6 (1.20g, 3.60mmol), 2.0M aqueous Na2CO3 (5mL) and another portion of PdCl2(dppf)-CH2Cl2 (0.084g, 0.103mmol), then heated at 110°C for 12h under argon. The reaction mixture was cooled to room temperature, filtered, and concentrated. The final compound was purified by MPLC (ISCO CombiFlash purification system) (MeOH/DCM, eluted from 0% to 10%), The fractions were collected, concentrated to afford 12a (0.72g, 57.2% yield).
Re: Поиск по Реаксис
Закрыл. Больше ничего не нашлось?
Re: Поиск по Реаксис
оставшиеся в одном поиске
синтез дигидрокси реаксис не находит
синтез дигидрокси реаксис не находит
У вас нет необходимых прав для просмотра вложений в этом сообщении.
Re: Поиск по Реаксис
Спасибо
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