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1) A. N. Krasovskii, N. M. Turkevich, M. I. Yurchenko, P. M. Kochergin, and I. I. Soroka, Ukr. Khim. Zh. (Russ. Ed.), 514 (1982)
2) B. A. Priimenko, B. A. Samura, S. N. Garmash, N. A. Klyuev, and N. I. Romanenko, Khim.-Farm. Zh., 17, 160 (1983)
3) B. A. Priimenko, N. I. Romanenko, S. N. Garmash, N. I. Gnatov, and A. K. Sheinkman, Khim. Prir. Soedin., 623 (1980)
4) N. I. Romanenko, I. V. Fedulova, and V. V. Kirichenko, Khim.-Farm. Zh., 20, 1319 (1986)
5) M. V. Povstyanoi, A. V. Akimov, and P. M. Kochergin, Ukr. Khim. Zh., 40, 215 (1974)
6)M. V. Povstyanoi, P. M. Kochergin, A. V. Akimov, and V. V. Androsov, Izv. Vyssh. Uchebn. Zaved., Khim. Khim. Tekhnol., 18, 1316 (1975)
7) B. A. Priimenko, N. I. Romanenko, S. N. Garmash, and M. V. Povstyanoi, Izv. Vyssh. Uchebn. Zaved., Khim. Khim. Tekhnol., 24, 1495 (1981)

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1. 2,3-Dihydro-6,8-dimethylthiazolo[3,2-f]xanthin-3-one and its derivatives at the methylene group Full Text

By Krasovskii, A. N.; Turkevich, N. M.; Yurchenko, M. I.; Kochergin, P. M.; Soroka, I. I.
From Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1982), 48(5), 514-17. | Language: Russian, Database: CAPLUS

The title compds. I (X = PhCH, p-MeOC6H4CH, m-, p-O2NC6H4CH, p-O2NC6H4CH:CClCH, 2-furfurylidene, 5-nitro-2-furfurylidene, 3-isatinylidene) were prepd. in 67-95% yields by condensation of aldehydes with I (X = H2) or in the case of the nitro derivs. by condensation with (carboxymethylthio)theophylline derivs. Coupling reaction of XN2+BF4- with I (X = H2) gave 69-98% I (X = PhNHN, p-MeC6H4NHN, o-ClC6H4NHN, o-O2NC6H4NHN, p-H2NSO2C6H4NHN).

2. Synthesis and pharmacological activity of 6H- and 6-alkyl-8-methylimidazo[1,2-f]xanthine derivatives Full Text

By Priimenko, B. A.; Samura, B. A.; Garmash, S. N.; Klyuev, N. A.; Romanenko, N. I.
From Khimiko-Farmatsevticheskii Zhurnal (1983), 17(2), 160-4. | Language: Russian, Database: CAPLUS

Alkylation of the K salt of 8-chloro-3-methylxanthine by XCH2COR1 (R1 = Me, Ph, X = halo) gave I which was cyclocondensed with RNH2 (R = Me, H, Ph, Bu, allyl, HOCH2CH2, PhCH2, cyclohexyl, homoveratryl, p-tolyl, p-EtO2CC6H4, anisyl) to give 60-93% II. Alkylation of II (R = Me, Ph, HOCH2CH2, R1 = Ph; R = HOCH2CH2, R1 = Me) by glycerin α-chlorohydrin, epichlorohydrin, or Me2C(OH)Cl gave 53-78% III [R2 = CH2CH(OH)Me (Q), etc.]. III (R = HOCH2CH2, R1 = Ph, R2 = Q), at a dosage of 10 mg/kg in white mice, increased diuretic activity over a control by 123.8% and, at the identical dosage in white rates, ethaminal induced sleep by 138.75%.

3. 1. Studies of xanthines and their condensed derivatives Full Text

By Priimenko, B. A.; Romanenko, N. I.; Garmash, S. N.; Gnatov, N. I.; Sheinkman, A. K.
From Khimiya Prirodnykh Soedinenii (1980), (5), 623-6. | Language: Russian, Database: CAPLUS

Alkylation of chloroxanthine I (R = H) with ClCH2CH2OH gave 55.3% I (R = CH2CH2OH), which was chlorinated by SOCl2 followed by cyclocondensation with amines to give 44.7-50.5% II (R1 = Ph, p-MeC6H4, p-MeOC6H4; R2 = H). Alkylation of II (R1 = Ph, R2 = H) with ClCH2CH2OH gave 73.1% II (R1 = Ph, R2 = CH2CH2OH). Treatment of II (R1 = p-MeC6H4, R2 = H) with P2S5 gave 69% III (R3 = SH), which was methylated and treated with H2NCH2CH2OH to give 20% III (R3 = NHCH2CH2OH).

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4. С 4-ой ссылкой что-то не так. Нет такой статьи в базе. Вот все ответы за 1986 год:


1. Chromatographic analysis of intermediates in vitamin A synthesis Full Text

By Staroverov, V. M.; Chuev, V. P.; Romanenko, V. P.
From Khimiko-Farmatsevticheskii Zhurnal (1986), 20(11), 1379-82. | Language: Russian, Database: CAPLUS

The purity of 1,1-dimethoxy-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-4-penten-3-one (I) and 1,1-dimethoxy-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-4-penten-3-ol (II) was monitored by gas chromatog. with a flame-ionization detector. The sepn. was carried out at 140° on a 1.2-m glass column with 1% E-301 on Inerton-Super. The main impurities in I and II were 1-methoxy-1-ethoxy-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-4-penten-3-one and I, resp. β-Ionone was identified as a volatile impurity in I.





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2. Synthesis and biological properties of (3-methyl-7-alkylxanthinyl-8)thioacetic acids derivatives Full Text

By Priimenko, B. A.; Romanenko, N. I.; Fedulova, I. V.; Orestenko, L. P.; Chervinskii, A. Yu.; Garmash, S. N.
From Khimiko-Farmatsevticheskii Zhurnal (1986), 20(11), 1322-4. | Language: Russian, Database: CAPLUS

The reaction of 3-methyl-7-alkyl-8-bromoxanthines with thioglycolic acid was investigated. The (3-methyl-7-alkylxanthinyl-8)thioacetic acids obtained reacted easily with Et alc. resulting in formation of corresponding ethers; (3-methyl-7-alkylxanthinyl-8)thioacetic acid hydrazides and hydrazide hydrazones were obtained from these ethers. Antimicrobial activity of the compds. synthesized are reported.






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3. The synthesis and pharmacological activity of the derivatives of 1-methyl-3H-6,9-dihydro-1,2,4-triazino[3,4-f]xanthine Full Text

By Romanenko, N. I.; Samura, B. A.; Fedulova, I. V.; Priimenko, B. A.; Chervinskii, A. Yu.; Garmash, S. N.
From Khimiko-Farmatsevticheskii Zhurnal (1986), 20(2), 187-90. | Language: Russian, Database: CAPLUS

Cyclocondensation of xanthines I (R = H, Me, R1 = Me, Et, Ph, p-EtC6H4) with R2NHNH2 (R2 = Et, H, Me, Ph, p-HO2CC6H4) gave 30-79% triazinoxanthines II which (R, R1, R2 = H, Ph, Et; H, Et, Me) were treated with X(CH2CH2)2NH (X = O, CH2) and CH2O in a Mannich reaction to give 53 and 72% III. Triazinoxanthine II (R = H, R1 = Me, R2 = Et) prolonged ethaminal sleep in white rats 205% at 1/10 LD50 (33.5 mg/kg) i.v. at 3-5% aq. suspension.








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4. Synthesis and biological properties of substituted triazino[3,4-f]xanthines Full Text

By Romanenko, N. I.; Fedulova, I. V.; Priimenko, B. A.; Samura, B. A.; Kapkan, L. M.; Chervinskii, A. Yu.; Pekhtereva, T. M.; Garmash, S. N.
From Khimiko-Farmatsevticheskii Zhurnal (1986), 20(4), 427-30. | Language: Russian, Database: CAPLUS

Sixteen title compds. (I; R = H, Me; R1 = Ph, p-chlorophenyl, 3,4-dihydroxyphenyl, 2-thienyl; R2 = Et, Ph, H; R3 = H, CH2CO2Et, CH2CO2H, CH2CONHNH2) were prepd. by cyclic condensation of 7-acylmethyl-8-bromo-3-methylxanthines with appropriate hydrazines. Toxicol. study of most I showed them to be of very low i.p. toxicity in mice. Pharmacol. evaluations in rats showed that I (R = H; R1 = R2 = Ph; R3 = CH2CONHNH2) possesses marked psychoanaleptic properties, I (R = R3 = H; R1 = R2 = Ph) possesses neuroleptic activity 3-fold stronger than that of aminazine, and many I possess diuretic activity, esp. those contg. a Ph group at N-9.








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5. Synthesis, neurotropic and diuretic activity of 7,8-disubstituted 3-methylxanthines Full Text

By Samura, B. A.; Fedulova, I. V.; Romanenko, B. A.; Priimenko, B. A.; Chervinskii, A. Yu.; Garmash, S. N.; Troshin, D. A.
From Khimiko-Farmatsevticheskii Zhurnal (1986), 20(1), 52-5. | Language: Russian, Database: CAPLUS

The title compds. I (R = Ph, CH2OPh, CH(OH)C6H4NO2-p, R1 = 2-furylmethylamino, morpholino, hexamethylenimino, NHCH2CH2OH, NEt2, piperazino, SCH2CO2H), useful as psychotropics and diuretics, were prepd. in 24-94% yields from I (R1 = Br) by amination with appropriate amines or by reaction with HSCH2CO2H. The hydrochloride of I [R = CH(OH)C6H4NO2-p, R1 = piperazino] increased urinary flow 180.7% compared to a control and potentiated narcotic sleep 147.0% compared to a control.








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6. Some physiological and biochemical properties of Catharanthus roseus Full Text

By Kuznetsova, G. K.; Shain, S. S.; Romanenko, V. I.
From Khimiko-Farmatsevticheskii Zhurnal (1986), 20(7), 851-5. | Language: Russian, Database: CAPLUS

Various physiol and biochem. aspects of C. roseus were examd. Altering the wavelength of incident light or the photoperiod changed the time required to induce flowering; both longer photoperiod and white light (as opposed to blue or red) stimulated flowering. Leaf content of chlorophylls a and b also responded to daylength and light quality. Vinblastine and leurosine were higher in plants with good chlorophyll app. activity, indicating a role for photosynthesis. Both alkaloids increased upon UV irradn. Water stress affected alkaloid content and biomass more than chlorophyll content. Cytokinin content of C. roseus branches during fruit-ripening and the effect of light on germination were also examd.

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5. Single-stage synthesis of 1,4-dihydro derivatives of as-triazino(3,4-f)xanthine Full Text

By Povstyanoi, M. V.; Akimov, A. V.; Kochergin, P. M.
From Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1974), 40(2), 215-16. | Language: Russian, Database: CAPLUS

The triazino[3,4-f]xanthines (I, R = Ph, p-O2NC6H4, p-BrC6H4; R1 = H, Ph) were prepd. by treating 8-bromotheophylline (II, R2 = H) with BrCH2COR to give the intermediate II (R2 = CH2COR) which was treated with R1NHNH2 to give the hydrazone II(R2 = CH-2CR:NNHR1) followed by cyclization. The intermediates were not isolated.

6. Synthesis of 1,4-dihydro-1,2,4-triazino[3,4-f]xanthines Full Text

By Povstyanoi, M. V.; Kochergin, P. M.; Akimov, A. V.; Androsov, V. V.
From Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1975), 18(8), 1316-19. | Language: Russian, Database: CAPLUS

The K salt of 8-bromotheophylline underwent successive substitution reaction with BrCH2COR (R = Me, Ph, 4-MeC6H4, 4-MeOC6H4, 2-thienyl) and cyclocondensation with R1NHNH2 (R1 = H, Me, Pr, Ph, 2-pyridinyl) to give the title compds. I.

7. Synthesis and study of the reactivity of 1,4-dihydro-1,2,4-triazino(3,4-f)xanthines Full Text

By Priimenko, B. A.; Romanenko, N. I.; Garmash, S. N.; Povstyanoi, M. V.
From Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1981), 24(12), 1495-9. | Language: Russian, Database: CAPLUS

8-Chloro-3-methylxanthine and KOH gave the K salt, which was acylated with ClCH2COMe or BrCH2COPh, then cyclized with a hydrazine to give I (R, R1, and % yield = Me, H, 78.3; Me, Me, 68; Ph, H, 68; Ph, Me, 83.8; Ph, Et, 71; Ph, Ph, 56.4). Several reactions of I were studied; e.g., I (R = Ph, R1 = H) and N-bromosuccinimide gave II, and I (R = R1 = Ph) and P2S5 gave III.

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