Efficient Synthesis of Novel NK1 Receptor Antagonists: Selective 1,4-Addition of Grignard Reagents to 6-Chloronicotinic Acid Derivatives
Fabienne Hoffmann-Emery, Hans Hilpert, Michelangelo Scalone, and Pius Waldmeier
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http://dx.doi.org/10.1021/jo0523666Substituent Effects of N-(1,3-Diphenyl-1H-pyrazol-5-yl)benzamides on Positive Allosteric Modulation of the Metabotropic Glutamate-5 Receptor in Rat Cortical Astrocytes
Tomas de Paulis, Kamondanai Hemstapat, Yelin Chen, Yongqin Zhang, Samir Saleh
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http://dx.doi.org/10.1021/jm051252j(+)-(2R,5S)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist
Isao Kinoyama,* Nobuaki Taniguchi, Akira Toyoshima,† Eisuke Nozawa, Takashi Kamikubo, Masakazu Imamura
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http://dx.doi.org/10.1021/jm050293c