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[Medz]

Помогите, пожалуйста, найти методики синтеза данного соединения:
N,N-dibutylbenzene-1,4-diamine
2836-02-4
C1(N)=CC=C(N(CCCC)CCCC)C=C1

MoleculeDepictor (27).png

C1.mol

[mishka]

из N,N-dibutyl-4-nitroaniline

With hydrogen; platinum on activated charcoal In methanol

Gamage, Swarna A.; Figgitt, David P.; Wojcik, Stanley J.; Ralph, Raymond K.; Ransijn, Adriana; Mauel, Jacques; Yardley, Vanessa; Snowdon, Diane; Croft, Simon L.; Denny, William A.
[Journal of Medicinal Chemistry, 1997, vol. 40, # 16, p. 2634 - 2642]


With hydrogen; palladium 10% on activated carbon In methanol at 20℃; for 4h;

Experimental Procedure
Current Patent Assignee: ABBVIE - US2005/14794, 2005, A1
Location in patent: Page 26
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N,N-dibutyl-phenylenediamine+bromine-> бромид...

With 1,4-dioxane; acetic acid at 0℃;
Milligan
[Journal of the American Chemical Society, 1950, vol. 72, p. 2775]
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еще есть в

Reilly; Hickinbottom
[Journal of the Chemical Society, 1918, vol. 113, p. 109]
====

Experimental Procedure
The following 4-substituted anilines were prepared: ... N-butyl-N-methylbenzene-1,4-diamine N-benzyl-N-butylbenzene-1,4-diamine N,N-dibutylbenzene-1,4-diamine (4aR,8aS)-4-(octahydroisoquinolin-2-yl)phenylamine ...


Current Patent Assignee: AVENTIS PHARMA DEUTSCHLAND - US2003/212070, 2003, A1

[Medz]

Большое спасибо !!!