+++Поиск в Реаксис, thank you mishka !

[maks]

уважаемые коллеги ,посмотрите пожалуйста синтез
5,7-Difluoro-DL-tryptophan
CAS 53314-96-8
NC(CC1=CNC2=C(F)C=C(F)C=C12)C(O)=O

такой Smiles Code дает его производитель Amatek Chemistry , в другом каком-то абстрактном месте Smiles
рисуют иначе, скорее всего это одно и тоже ,не слишком разбираюсь
CAS 53314-96-8
C12C(F)=CC(F)=CC=1C(CC(C(O)=O)N)=CN2

[mishka]

(одна ссылка)
из 2-acetylamino-3-(5,7-difluoro-1H-indol-3-ylmethyl)-propionic acid

Stage #1: 2-acetylamino-3-(5,7-difluoro-1H-indol-3-ylmethyl)-propionic acid With hydrogenchloride In water for 4h; Heating / reflux;
Stage #2: With sodium acetate In water at 50℃;

Experimental Procedure
Current Patent Assignee: BAYER SCHERING PHARMA - WO2008/71455, 2008, A1
Location in patent: Page/Page column 98

39.39e
The solution of 2-Acetylamino-3-(5,7-difluoro-1 H-indol-3-yl)-propionic acid (2.8 g) in 2N HCI (25 ml) was refluxed for 4 hr under Ar. After cooling at rt the solvent was removed under reduced pressure at 500C. The residue (-2.7 g) was dissolved in water (6 ml) and sodium acetate (0.85 g) was added at 500C. After cooling at rt the reaction mixture was left in the freezer (O0C) overnight. The solid formed was filtered off, washed with cold water (2 ml) and dried yielding after recrystallization from abs. EtOH 2.0 g of the title compound. MS (ESI,+): 241 (M+1 ).