+++Поиск по Reaxys/SF Спасибо, mishka!

[mbshch]

Здравствуйте!
Пожалуйста, помогите с поиском методик синтеза и свойств следующего соединения:

O=C([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC1=CNC=N1)=O)C)=O)CCC(O)=O)=O)N

Заранее благодарю

[mishka]

Reax
биоактивность описана в Current Patent Assignee: VLT - US9334303, 2016, B2 Peptide compound useful for inhibiting amyloid plaque formation

о получении сведений нет

[mishka]

SF (1373826-23-3)
получение и(или) реакции (не разбирался) описаны в

Ac-His-Ala-Glu-Glu-NHh2 peptide production method
Assignee: AO Opytno-Eksperimentalnyi Zavod "VladMiVa"
Russian Federation, RU2767030 C1 2022-03-16

Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice
By: Tsvetkov, Philipp O.; et al
Journal of Alzheimer's Disease (2015), 46(4), 849-853

есть еще разные соли для моно(ди)калиевой получение в

Potassium salt of HAEE peptide for treating neurodegenerative diseases
Assignee: Limited Liability Company "Lifemission"
World Intellectual Property Organization, WO2024014980 A1 2024-01-18

Potassium salt of His-Ala-Glu-Glu peptide for the treatment of neurodegenerative diseases
Assignee: OOO "Laifmissiya"
Russian Federation, RU2784425 C1 2022-11-24


про аммониевую (1NH3, 2NH3) есть только references
HAEE synthetic tetrapeptide and derivatives thereof intended for human neuron function recovery
Assignee: Obshchestvo s Ogranichennoi Otvetstvennostyu "LAIFMISSYa"
Russian Federation, RU2822603 C1 2024-07-09


Ammonium salt of HAEE peptide for treating neurodegenerative diseases
Assignee: Limited Liability Company "Lifemission"
World Intellectual Property Organization, WO2024014984 A1 2024-01-18

Ammonium salt of HAEE peptide for the treatment of neurodegenerative diseases
Assignee: OOO "Laifmissiya"
Russian Federation, RU2784249 C1 2022-11-23

натриевая references
HAEE synthetic tetrapeptide and derivatives thereof intended for human neuron function recovery
Assignee: Obshchestvo s Ogranichennoi Otvetstvennostyu "LAIFMISSYa"
Russian Federation, RU2822603 C1 2024-07-09