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Посмотрите,пожалуйста,получение
CCOC(=O)C(=O)CC(=O)C(OC)OC
COC(OC)C(=O)CC(=O)C(=O)OC
Спасибо!
+++Поиск в Reaxys
+++Поиск в Reaxys
Последний раз редактировалось urri Чт янв 26, 2023 10:27 am, всего редактировалось 1 раз.
Re: Поиск в Reaxys
есть только получение
ethyl 5,5-dimethoxy-2,4-dioxopentanoate из Pyruvic aldehyde dimethyl acetal и oxalic acid diethyl ester
With sodium ethanolate In ethanol at 20℃; for 2h;
Experimental Procedure
81%
Current Patent Assignee: CONNEXIOS LIFE SCIENCES PVT - WO2014/202528, 2014, A1
Location in patent: Page/Page column 76; 77
Abstract
15a Intermediate 1 5a: Ethyl 5,5-dimethoxy-2,4-dioxopentanoate
To a solution of 1,1-dimethoxypropan-2-one (1.0 g, 8.0 mmol) and diethyl ethanedioate (1.48 g, 10.0 mmol) in dry ethanol, freshly prepared sodium ethoxide solution in ethanol was added at room temperature and stirred for 2 h. The reaction mixture was concentrated and the obtained title product (4.0 g, 81 .0%) , which wasused as such for the next step.
With diethyl ether; sodium ethanolate
Umio
[Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 1048,1052][Chem.Abstr., 1960, p. 5611]
ethyl 5,5-dimethoxy-2,4-dioxopentanoate из Pyruvic aldehyde dimethyl acetal и oxalic acid diethyl ester
With sodium ethanolate In ethanol at 20℃; for 2h;
Experimental Procedure
81%
Current Patent Assignee: CONNEXIOS LIFE SCIENCES PVT - WO2014/202528, 2014, A1
Location in patent: Page/Page column 76; 77
Abstract
15a Intermediate 1 5a: Ethyl 5,5-dimethoxy-2,4-dioxopentanoate
To a solution of 1,1-dimethoxypropan-2-one (1.0 g, 8.0 mmol) and diethyl ethanedioate (1.48 g, 10.0 mmol) in dry ethanol, freshly prepared sodium ethoxide solution in ethanol was added at room temperature and stirred for 2 h. The reaction mixture was concentrated and the obtained title product (4.0 g, 81 .0%) , which wasused as such for the next step.
With diethyl ether; sodium ethanolate
Umio
[Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 1048,1052][Chem.Abstr., 1960, p. 5611]
Re: Поиск в Reaxys
Спасибо!
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