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SMILES: CC(C)OC(=O)C1=C(C)NC(C)=C(C1c2cc([N+]([O-])=O)ccc2)C(=O)OCCOc(cc3C(F)(F)F)ccc3
Заранее признателен за помощь!
++++ Спасибо тов. mishka!
++++ Спасибо тов. mishka!
Последний раз редактировалось dolmen Пн ноя 21, 2022 6:38 am, всего редактировалось 1 раз.
Re: Поиск в SF или Reaxys
реаксис
Melting Point, °C
128 - 130
Current Patent Assignee: BAYER AG - US4675329, 1987, A
получение
2-(3-trifluoromethylphenoxy)-ethyl 2-(3-nitrobenzylidene)-acetoacetate + isopropyl acetoacetate
In dichloromethane; isopropyl alcohol
выход - 28 g (51%)
Current Patent Assignee: BAYER AG - US4675329, 1987, A
Experimental Procedure
D Isopropyl 2-(3-trifluoromethylphenoxy)-ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate STR10
(D) 42.3 g (0.1 mole) of 2-(3-trifluoromethylphenoxy)-ethyl 2-(3-nitrobenzylidene)-acetoacetate were heated under reflux together with 14.4 g (0.1 mole) of isopropyl acetoacetate and 12 g (0.18 mole) of a 25% strength aqueous ammonia solution in 150 ml of isopropanol in a nitrogen atmosphere for 24 hours. After the reaction mixture had cooled, the solvent was distilled off in vacuo and the oily residue was taken up in methylene chloride. The organic phase was washed with water and, after drying over anhydrous sodium sulphate, was concentrated in vacuo. The resulting oil was made to crystallize and the crude product was filtered off with suction and recrystallized from ethanol. Melting point: 128°-130° C. YielВ: 28 g (51%).
В SF
таже ссылка (патент той же ...family...
AT50565T;CA1257600A;DE3424342A1;EP0167068A2;EP0167068A3;EP0167068B1;JPS6118763A;US4675329A)
Isopropyl 2-[3-(trifluoromethyl)phenoxy]ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, its preparation and use as a peripheral vasodilator
By: Wehinger, Egbert; Knorr, Andreas; Stoepel, Kurt; Heise, Arend
Federal Republic of Germany, DE3424342 A1 1986-01-09
The title compound (I), useful as peripheral vasodilator (no data), was prepared by 6 methods. Refluxing 3-O2NC6H4CH:C(COMe)CO2CHMe2 with MeC(NH2):CHCO2CH2CH2OC6H4CF3-3 in EtOH 20 h gave 64% I.
Melting Point, °C
128 - 130
Current Patent Assignee: BAYER AG - US4675329, 1987, A
получение
2-(3-trifluoromethylphenoxy)-ethyl 2-(3-nitrobenzylidene)-acetoacetate + isopropyl acetoacetate
In dichloromethane; isopropyl alcohol
выход - 28 g (51%)
Current Patent Assignee: BAYER AG - US4675329, 1987, A
Код: Выделить всё
https://worldwide.espacenet.com/patent/search/family/006239659/publication/US4675329A?q=pn%3DUS4675329
D Isopropyl 2-(3-trifluoromethylphenoxy)-ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate STR10
(D) 42.3 g (0.1 mole) of 2-(3-trifluoromethylphenoxy)-ethyl 2-(3-nitrobenzylidene)-acetoacetate were heated under reflux together with 14.4 g (0.1 mole) of isopropyl acetoacetate and 12 g (0.18 mole) of a 25% strength aqueous ammonia solution in 150 ml of isopropanol in a nitrogen atmosphere for 24 hours. After the reaction mixture had cooled, the solvent was distilled off in vacuo and the oily residue was taken up in methylene chloride. The organic phase was washed with water and, after drying over anhydrous sodium sulphate, was concentrated in vacuo. The resulting oil was made to crystallize and the crude product was filtered off with suction and recrystallized from ethanol. Melting point: 128°-130° C. YielВ: 28 g (51%).
В SF
таже ссылка (патент той же ...family...
AT50565T;CA1257600A;DE3424342A1;EP0167068A2;EP0167068A3;EP0167068B1;JPS6118763A;US4675329A)
Isopropyl 2-[3-(trifluoromethyl)phenoxy]ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, its preparation and use as a peripheral vasodilator
By: Wehinger, Egbert; Knorr, Andreas; Stoepel, Kurt; Heise, Arend
Federal Republic of Germany, DE3424342 A1 1986-01-09
The title compound (I), useful as peripheral vasodilator (no data), was prepared by 6 methods. Refluxing 3-O2NC6H4CH:C(COMe)CO2CHMe2 with MeC(NH2):CHCO2CH2CH2OC6H4CF3-3 in EtOH 20 h gave 64% I.
Код: Выделить всё
https://worldwide.espacenet.com/patent/search/family/006239659/publication/DE3424342A1?q=DE3424342A1
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