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[urri]

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NC(=O)n1nccc1N

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ИЗОКсазол + semicarbazide hydrochloride


Conditions Yield Reference
Stage #1: ISOXAZOLE With sodium ethanolate In ethanol at 20℃; for 2.5h;
Stage #2: semicarbazide hydrochloride With acetic acid In ethanol at 95℃; for 2h;
52%
Lefoix, Myriam; Mathis, Gérald; Kleinmann, Tirtsa; Truffert, Jean-Christophe; Asseline, Ulysse
[Journal of Organic Chemistry, 2014, vol. 79, # 7, p. 3221 - 3227]



Stage #1: ISOXAZOLE With sodium ethanolate In ethanol at 0℃; for 0.5h;
Stage #2: semicarbazide hydrochloride With acetic acid In water at 25℃; for 16h; pH=7;

Experimental Procedure
21.6%
Current Patent Assignee: ATKINSON ROBERT N - US2012/77814, 2012, A1
Location in patent: Page/Page column 46

...........................
из 2-(2-cyanoethenyl)-hydrazinecarboxamide
With triethylamine In ethanol; water

Current Patent Assignee: AMERICAN CYANAMID INC - US5358947, 1994, A
........................
cyanoacetaldehyde + semicarbazide hydrochloride

In water for 5h;
2.4 g
Chu, C. K.; Watanabe, K. A.; Fox, J. J.
[Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1435 - 1439]

[urri]

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