+++Поиск по Reaxys

[Кокаколик]

Здравствуйте!
Помогите, пожалуйста, с поиском методик синтеза следующих соединений:

1.
4,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Chemical Formula: C7H8N4O
O=C1C=C(C)N(C)C2=NC=NN21

2.
2,4,5-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Chemical Formula: C8H10N4O
O=C1C=C(C)N(C)C2=NC(C)=NN21

3.
2-ethyl-4,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Chemical Formula: C9H12N4O
O=C1C=C(C)N(C)C2=NC(CC)=NN21

Заранее спасибо!

[mishka]

есть только получение 4,5-Dimethyl-s-triazolo<1,5-a>pyrimidin-7(4H)-on
из 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine + N,N-dimethyl-formamide dimethyl acetal

Hempel, Ute; Lippmann, Eberhard; Tenor, Ernst
[Zeitschrift fur Chemie, 1990, vol. 30, # 9, p. 320 - 321]

и
из
5-Methylamino-s-triazol, Acetessigsaeure-aethylester, 180-210grad; neben 4,7-Dimethyl-s-triazolo<1,5-a>pyrimidin-5(4H)-on;
или из
5-Methyl-7-methoxy-s-triazolo<1,5-a>pyrimidin, 180grad; neben 3,5-Dimethyl-s-triazolo<1,5-a>pyrimidin-7(3H)-on;
или из
5-Methylamino-s-triazol, Acetessigsaeure-aethylester, Eg., Siedetemp.; neben 4,7-Dimethyl-s-triazolo<1,5-a>pyrimidin-5(4H)-on;
в
Makisumi; Kano
[Chemical and pharmaceutical bulletin, 1963, vol. 11, p. 67,70,73]


из
Ag-Salz von 5-Methyl-s-triazolo<1,5-a>pyrimidinol-(7), Methyljodid, wfr. Py., Bzl., Siedetemp.; neben 3,5-Dimethyl-s-triazolo<1,5-a>pyrimidin-7(3H)-on;
и
5-Methyl-s-triazolo<1,5-a>pyrimidinol-(7), Dimethylsulfat, wss. NaOH, 45-50grad; neben 3,5-Dimethyl-s-triazolo<1,5-a>pyrimidin-7(3H)-on;
в
Mikisumi
[Chemical and pharmaceutical bulletin, 1963, vol. 11, p. 129]

или
thermisch aus (6);
Wagner et al.
[Pharmazie, 1975, vol. 30, p. 134,139]

тему по правилам закройте (+++ проставьте)